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Video s3
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    Author(s)
    Display Name
    Timothy Zhang
    Affiliation
    Affiliation
    McGill University
    Affiliation
    Affiliation
    York University
    Display Name
    Jason Eshraghian
    Affiliation
    Affiliation
    UC Santa Cruz
    Affiliation
    Affiliation
    James Cook University
    Display Name
    Roman Genov
    Affiliation
    Affiliation
    University of Toronto
    Display Name
    Brandon Xia
    Affiliation
    Affiliation
    McGill University
    Abstract

    Single-cell RNA sequencing is an emerging technique in the field of biology that departs radically from the previous assumption of gene-expression homogeneity within a tissue. The large quantity of data generated by this technology enables discoveries of cellular biology and disease mechanics that are previously not possible and calls for accurate, scalable, and efficient processing pipelines. In this work, we propose SSCAE (spiking single-cell autoencoder), a novel SNN-based autoencoder for sc-RNA-seq dimensionality reduction. We apply this architecture on a variety of datasets, and the results show that it can match and surpass the performance of current state-of-the art techniques. Moreover, the potential of this technique lies in its ability to be scaled up and to take advantage of neuromorphic hardware, circumventing the memory bottleneck that currently limits the size of sequencing datasets that can be processed.