Recently, electrical stimulation has been widely used for biomedical applications, such as cardiac pacemaker, cochlear implant, muscle exercising, vision restoration, and seizure suppression. This paper presents two compact and power-efficient optimized neural stimulators for seizure suppression. These neural stimulators compromise between various design trade-offs such as adaptability with the load variations, multi-waveform generation for different seizures suppression, power efficiency, and linearity issues. The first design is an adaptable closedloop current stimulator with a bipolar electrode, while the other design is a multi-waveform open-loop current stimulator with a unipolar electrode. Finally, the first design optimizes the power consumption to 429.68 µW and occupies 0.11 mm . However, the second design achieves a high-power efficiency equals 96.47 % and occupies 0.015 mm . Both stimulators are implemented using UMC 0.13 µm CMOS technology.