This work contributes to the integration of microfluidic sample testing in platforms such as Lab-on-a-chip, by describing the design of a simple microdroplet generator system that could be implemented on such platforms for the purpose of biological liquid’s sampling. The system was first simulated with the ANSYS Fluent software for fluid dynamics by starting with an initial geometry and varying different parameters to measure the induced variations on the microdroplets generated by such a system. The simulation results can then help predict different microdroplet patterns in a given generation system, making it possible to determine the ideal conditions under which microdroplet generation can be achieved for a chosen geometry.