A powerful approach to study brain circuits in health and disease consists in coupling optogenetic neuromodulation with new generations of CMOS-based implantable neural probes that can provide sub-millisecond recordings from thousands of closely spaced electrodes. Here, we experimentally investigate the performances of 4-shank SiNAPS CMOS probes with 1024 electrodes to record light-evoked responses from wide brain areas in mice. Proof-of-concept results demonstrate the performances of SiNAPS probes to simultaneously acquire evoked activity (LFPs and APs) across multiple brain circuits and wide brain area.