The objective of this tutorial is to provide the attendees with key advancements of Artificial Intelligence (AI) and related Machine Learning (ML) technologies and their applications in the design of energy-efficient electronic circuits. The tutorial intends to provide an update/overview and to open a dialog on how to address the challenges faced in the design process. The different pathways to innovate through electronic systems design will be discussed through use cases selected from our ongoing projects, followed by a discussion on some opportunities.