Integrated Circuits (ICs) are mostly sensitive to irradiations (e.g., protons, heavy-ions, etc.)in space, leading to various Single-Event Effects (SEEs). Among different SEEs, Single-Event Latch-up (SEL) is one of the most critical because it is detrimental and often damages ICs. This paper reports a circuit implementation that serves to provide protection for COTS ICs from SEL. The on-ground hardware verification on the basis of Californium 252 depicts that the circuit successfully cuts off the SEL current and subsequently resets the COTS IC. The reported circuit has been adopted in a 1U CubeSat that will be launched early 2020.