As quantum processors grow in complexity, the focus is shifting towards the scaling of the entire quantum computing system, including the quantum hardware but as well the classical support electronics. Silicon-based quantum computing offers the enticing possibility that the quantum processor, the quantum-classical interface, and the classical layer can all, in principle, be manufactured using complementary metal-oxide semiconductor (CMOS) technology, creating an opportunity to move from distributed quantum–classical systems to integrated quantum computing solutions. Here, we review the state-of-the-art in spin-based quantum computing in silicon and present different approaches to help scale the technology using CMOS technology. We discuss the use of industry-manufactured silicon devices as the basic qubit element and present radio-frequency reflectometry techniques for fast high-fidelity spin readout. Finally, we show how quantum-classical co-integration can enable large-scale control and readout via frequency- and time-domain multiplexing