This paper presents a portable biosensing system consisting of a bioimpedance measurement circuit and an IDE chip. This system can be modified to detect various biomolecules, including DNA, antigen/antibody, proteins, metabolites, etc. The bioimpedance measurement circuit has a fast speed (obtaining results within 1.1 miliseconds), and its error levels are within 0.5% and 0.1% in terms of accuracy and precision, respectively. The proposed system can function similarly to the commercialized electrochemical workstation (Biologic SP-200) and is 36 times faster in the measurement than the latter. Furthermore, the system can be a point-of-care diagnostic tool because of its low-cost and portability.