In this paper, we propose self-interference (SI) cancellation in cooperative multiple-input multiple-output (Co-MIMO) for full-duplex (FD) wireless communication systems. This proposal solves SI by applying the block diagonalization used in multi-user MIMO. Therefore, there is no need for a radio frequency (RF) canceller, which has a large hardware (HW) size and is difficult to extend to MIMO. Furthermore, we can achieve higher throughput by applying Co-MIMO, in which multiple access points (APs) work together to communicate. The proposed method's implementation uses field-programmable gate array (FPGA) and software-defined radio (SDR). In the experiment, a total of 30 [dB] SI can cancel with two cooperative APs and two antennas per AP in the IEEE 802.11 system.