This paper presents a fast Affine Motion Estimation (AME) of Versatile Video Coding (VVC) Standard, based on Machine Learning and using Random Forest (RF) classification method. This encoding approach develops an RF model for each block size. The models were trained with information extracted during the VVC encoding process of the current, parent, and neighboring Coding Units (CU). Each model is applied to predict whether the Affine Motion Estimation (AME) will be skipped or not for that CU size. The proposed solution achieves a reduction of 20% on average in AME encoding time, with an insignificant impact of 0.07% on BD-BR.