In this paper, a multi-functional automated integrated CMOS platform for nanopore-based DNA sequencing is presented. The platform equipped with 16*8 biosensor array for nanopore detection is also able to perform bilayer lipid membrane capacitance detection and nanopore insertion pulse generation, realizing the whole process automated auxiliary function from transducer preparation to DNA sequencing. Post layout simulation shows that each cell consumes only 37.366µW while the whole system occupying 1.633mm².