This paper presents a fully-implantable closed-loop opto-electro stimulation interface for motor neuron disease treatment, designed for experiments with freely moving rodents. A low power consumption Bluetooth data link is used to control 64 opto-electro stimulation channels and wirelessly receive neural recording data. The implant is powered by a wirelessly rechargeable lithium-ion battery, which can support 2.5 hours continuous operation with a stimulation output up to 10 mA. The battery is recharged using a QI standard wireless inductive power link, which can deliver >100 mW power at a distance of 2 cm. The total size of the implant system is 29 mm × 20 mm × 13 mm. Comparison of the performance of the proposed system with state-of-the-art is provided.