This paper presents a miniatured low noise, low power, and high-sensitive malaria diagnosis based on the magnetoresistance sensor with a CMOS analog front-end readout circuit for detection of paramagnetic property of hemozoin. The finite-element simulation is employed for hemozoin particles to prove that the magnetic field generated from a multi-hemozoin particle system is within the sensing range of MR sensors. A CMOS readout circuit is designed to convert the tiny current from MR sensors and suppress high frequency and large amplitude noises. The proposed system provides an immediate response to hemozoin samples and has the potential to diagnose malaria.