Wearable devices are easy to use, small, low power devices that can benefit people in their everyday lives. They are made with small form factor, comfortable fit, and unparalled function in mind. The inherent challenge in making a better device is to provide an overview of the user’s health for an elongated period of time with minimal recharging or replacement of sensors. Sensors made by semiconductor processes such as accelerometers, thermometers and photoplethysmogram (PPG) have been the pillars of the commercial wearable industry; however, these fail to interact with actual biological samples. A need for analog front-ends tailored for biosensors has risen in recent years. These rely on antigen-antibody interactions. This work demonstrates how a relatively large number of antibody-functionalized biosensors can be interfaced in size-constrained circuit design more efficiently than a row-column decoding scheme.