This work describes the implementation of SPACEMan, a wireless electrochemical system with concurrent potentiometric and amperometric sensing that can be utilised for saliva, sweat or point of care diagnostics. This system is designed with the vision of simpler interfaces for biofluid analysis. With a complete system-on-chip including electrochemical sensing, power management and data transmission, conventional interfaces like wirebonds will no longer be required in postprocessing steps.