Virtual-Reality (VR), Augmented-Reality (AR) and Mixed-Reality (MR) are finding new applications in clinical investigations. This study uses VR, AR, and MR techniques for pre-surgery applications on three platforms: Windows PC, Apple iPad, and Mobile. Using the proposed technique, which involves the use of virtual reality, augmented reality, and mixed reality technologies, a physician can visualize the problem and discuss options with a patient while the patient's anatomy is being studied. The combination of endoscopic visualization can be used for surgical planning, training, medical diagnosis, and postoperative examination.