A miniaturized discrete system developed for long-term peripheral nerve monitoring after injury, using impedance monitoring during nerve regeneration, has been developed in this work. The device uses programmable sinusoidal currents that are injected into tissue and the resulting potentials developed are measured to calculate the impedance of the nerve. It features a single current source and two single pole triple throw (3:1) switches for measuring between any pair of 4 electrodes. In addition, a procedure for developing a polydimethylsiloxane (PDMS) cuff to embed platinum ring electrodes and eventually electronics is also presented.